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Nonetheless, in distinction to expectations, NCAM1 polysialylation was not prevented in PrP ko cells but arrived at even increased amounts--the latter presumably a consequence of the higher stages of NCAM1 substrate expressed in these clones. To discover the scope of PrP's influence on NCAM1 polysialylation, we subsequent in contrast PSA-NCAM1 ranges in chosen mind locations and sciatic nerves in